报告题目：What we know about silk as biomaterials for biomedical applications?
报告人：S. C. Kundu（University of Minho, Portugal）
报告时间：9月12日（周一）下午15:30-16:30
报告地点：18号楼218会议室
Prof. Kundu obtained his post graduate and Ph.D degrees in genetics from Banaras Hindu University, India. Then, he carried out post-doctoral work at Institute of Molecular Biology, Moscow, Department of Biology, York University, Canada, Medical University, Lubeck, Germany and Department of Biology & Biochemistry, Brunel University, UK. Dr. Kundu trained under and post–graduate, pre-doctoral students in genetics, recombinant DNA technology, cell & molecular biology. Dr. Kundu’s research interest is still in silk biomaterials for biomedical applications. He published 130 major research papers in peer reviewed high impact journals using as silk biomaterials. Dr. Kundu earlier worked as faculty at Department of Biotechnology, Indian Institute of Technology, Kharagpur. He recently joined 3Bs Research Group at University of Minho as ERA Chair Full Professor under European Commission Programme from September 01, 2016. He will lead 3D Cancer Disease Model for drug screening in European Research Area.
Abstract
Biomaterial scaffolds/matrices are attracting considerable interests that induce regeneration of tissues and organs based on similar analogs of the extracellular matrix. Silk proteins fibroin and sericin are now becoming attractive biomaterials. Silk fibroin, the core protein, is hydrophobic in nature while sericin is hydrophilic glue like protein. The characteristics of silks, including biodegradability, biocompatibility, controllable degradation rates, and versatility to generate different material formats attract interest in the field of biomaterials for regenerative medicine. With the help of various technologies, thin films, porous 3D scaffolds hydrogels, nanoparticles, macro patterned surface coating, micro-beads, are developed from the mulberry and perse non-mulberry silk proteins for biomedical and tissue engineering purposes. The cell culture and tissue formation on silk-based biomaterials show appropriate cell adhesion, proliferation, and differentiation. The use silk sericin and fibroin as surface coating materials on titanium facilitates osteoblast cell adherence and proliferation. We also use silk fibroin matrices as 3D model for cancer investigation. Similarly sericins are also tested for their cytocompatibility and biomaterial potential including delivery of gene and/or drug and skin tissue engineering. Silk protein is also proved to be as bioelectronics materials. The results of the work will be discussed.
