Preparation and Drug Release Properties of CO2 Stimulus-sensitive Poly (N, N-dimethylaminoethyl methacrylate)-b-polystyrene Nanoparticles.


作者:Xiaohong Wang, Guohua Jiang*, Zhen Wei, Xia Li, Bolin Tang 

关键字:miniemulsion RAFT polymerization; CO?2 stimulus-sensitive; nanoparticles; 

              drug release. 

论文来源:期刊 

具体来源:European Polymer Journal 

发表时间:2013年  

       The CO2 stimulus-sensitive nanoparticles based on poly (N, N-dimethylaminoethyl methacrylate)-b-poly styrene (PDMAEMA-b-PS) were prepared via surfactant-free miniemulsion reversible addition-fragmentation chain transfer (RAFT) polymerization. The as-prepared nanoaprticles exhibited core-shell structure with about 120 nm in diameter. Their dispersion/aggregation in water can be adjusted by alternatively bubbling of CO2 and N2. Drug release from these nanoparticles can be accelerated (or delayed) by bubbling (or removing) of CO2.

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